Sammanfattat
Fosfatidyletanol (PEth) kan bildas bara i närvaro av etanol. Specificiteten är hög (teoretiskt 100 procent).
Falskt positiva resultat har inte påvisats, och sensitiviteten är högre än för CDT, MCV och gamma-GT såväl var för sig som i kombination.
Det finns ett samband mellan redovisad alkoholkonsumtion de senaste 2 veckorna före provtagningen och mätvärdet.
Ett enstaka berusningstillfälle ger inga mätbara halter av PEth. Halveringstiden är cirka 4 dygn. PEth kan, beroende på utgångsvärde, påvisas upp till 4 veckor efter avslutat alkoholintag.
Referenser
1.Alcohol policy in the WHO European region: current status and the way forward. Fact sheet EURO/10/05. Available from: http://www.euro.who.int/document/mediacentre/fs1005e.pdf
2.Alkohol, droger och trafik. Vägverket 2008-06. Available from: http://publikationswebbutik.vv.se/upload/1745/88294_alkohol_droger_trafik_6.pdf
3.Nationella resultat från folkhälsoenkäten 2007 Hälsa på lika villkor?
Statens folkhälsoinstitut. http://www.fhi.se/templates/Page____12670.aspx
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Summary
Phosphatidylethanol (PEth) is an abnormal phospholipid that is formed only in the presence of alcohol (ethanol). Hence, the diagnostic specificity of PEth as an alcohol marker is theoretically 100 %. No false positive results have been recorded.
When more than moderate amounts of alcohol are regularly consumed, blood cells become enriched with PEth. Regular consumption for at least one week appears to be needed to give measurable amounts of PEth. There is a positive correlation between the amount of alcohol consumed and blood concentration of PEth. PEth has been shown to be a more sensitive indicator of alcohol consumption than CDT (Carbohydrate-deficient transferrin), GGT (Gamma-glutamyl transferase) and MCV (Mean corpuscular volume) or a combination of these. The half life of PEth in circulation is about 4 days, which means that PEth can be detected up to 4 weeks after ethanol has been cleared from the body.
Anders Isaksson, Lisa Walther, Christer Alling, Therese Hansson
Correspondance: Anders Isaksson, Klinisk kemi & farmakologi, Universitetssjukhuset S-221 85 Lund
anders.isaksson@skane.se
